The Optimal Balance between Oncolytic Viruses and Natural Killer Cells: A Mathematical Approach

Oncolytic virotherapy (OV) is a cancer therapy utilizing lytic viruses that specifically target cells for elimination. In this relatively new therapy, two contradictory observations have been made. Some studies showed immune responses including activated natural killer (NK) post oncolytic viral infection increased the cell death, while others reported such initial diminished anti-tumor efficacy, which was caused by premature clearance. paper, we present mathematical model to investigate effect of NK on virotherapy. Particularly, focused minimum condition be in terms parameters and how activation interacts changes dynamics among cancer, infected virus. Analytic works existence stability conditions equilibrium points are provided. Numerical results good agreement with analytic solutions. Our numerical show can created or destroyed dynamical system suggest balance between bursting rate virus crucial factor successful OV therapy.